S.E.M.I.: Side Effects May Include...
Hack and slash/Beat 'em up
Indie
Arcade
Action
Comedy
Party
Mostly Positive
47 reviews
January 23, 2026
Released 99 days ago
PC (Microsoft Windows)
About
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
Screenshots
Artwork
Release Dates by Platform
PC (Microsoft Windows)
Worldwide
Nov 20, 2025
PC (Microsoft Windows)
Worldwide
Jan 23, 2026
Game Info
- Developer
- Two Horn Unicorn
- Publisher
- Two Horn Unicorn
- Engine
- Unreal Engine 5
- Game Modes
- Single player, Multiplayer, Co-operative
- Perspective
- Third person
- Genres
- Hack and slash/Beat 'em up Indie Arcade
- Themes
- Action Comedy Party
Multiplayer
Online Co-op
Yes
Languages
- Audio / Voice
- Dutch, Chinese (Simplified), English, English (UK), Spanish (Spain), French, Japanese, Russian, Portuguese (Brazil)
- Text / Subtitles
- Chinese (Simplified), Dutch, English, English (UK), Spanish (Spain), French, Russian, Portuguese (Brazil), Japanese, German
